The passenger portion of the train did not derail and none of the 294 passengers aboard were injured, said Volusia County Fire Acting Division Chief Bill Medlin.
A problem with the track apparently caused the derailment about 4:15 p.m. after the train had left Sanford.
One of the 23 crew members aboard the train suffered a foot injury and was transported to a hospital, Medlin said.
The nine derailed cars were hauling 179 vehicles, Medlin said. One of the vehicle cars is on its side but still attached to the train.
A crane is expected to arrive about 8:30 p.m. to lift that vehicle car up and then crews will detach it from the train. Once that is done, the passenger portion of the train will continue north to its ultimate destination in Virginia, Medlin said.