Another thing of relevance to transcontinental travelers is that nearly all commercial airplane cabins are pressurized to the equivalent of an altitude of 8,000 feet. I even checked this once, taking an altimeter aboard and getting a readout of about 8,000 feet when the pilot told us we were at 35,000 feet. So unless you can get a ride on a ship passing through the Panama Canal or around the Horn, you will have to deal with an altitude of at least 5,000 feet or its equivalent if you want to travel from the east coast to the west coast of North America.