To increase the profit one need to truly understand what most potential business travelers as well as laid-back passengers are looking for in common and it's not available in both cars travel or air travel. It is the ability to comfort travel overnight without wasting precious day time, and sleeps with privacy and confidence of security (in a lockable private space)
With that in mind, long distance train should be cut into several mid-distance trains, with each route fit into 8~14 hours total riding time. Departs before the night on day 1, arrives next morning, adding more stops on both end, and skipping as much stops as possible in the middle.
In Europe, this is usually called "Hotel Train"
There are a few corridors where this could work in theory as supplemental service, not replacement for existing service.
However this would likely only happen if something incredibly major like the Green New Deal was somehow implemented in a big way in an effort to encourage rail travel in lieu of air travel.
What comes to mind is restoring the Night Owl between Washington and Boston, new overnight service from San Francisco to LA, added overnight service between Atlanta and New York, etc.
The Night Owl wouldn’t take a whole lot of new equipment – they could even decide to implement that in the next year or two once the new Viewliners come into service. The rest however would only likely happen with a bunch of new equipment that would have to be paid for by some major government program.