jis
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For Malaria, people in Malaria endemic areas develop limited immunity such that subsequent episodes are usually less severe. This is specially true if you get Malaria before your are in your late teens.Malaria also, even if you take Agent Orange's Favorite Med!!
Of course the other thing that happens is that US Blood Drives refuse to take your Blood if you frequently visit Malaria endemic areas. They have refused to take my blood ever since I started visiting India every year. During this period I have never had Malaria.